What does eyelash growth depend on?

Human eyelashes grow on the front lip of the eyelid margin. They are the second line of defense for the eyes, protecting them from external dust, sweat, foreign matter, and ultraviolet rays. They have the functions of shading, protecting, and expressing emotions. At the same time, eyelashes have the shortest lifespan among human hairs, with an average lifespan of 3-5 months (growth period, about 30 days; regression period, about 15 days; transition to resting period, about 100 days).

What is the difference between minoxidil and myristoyl pentapeptide 17? Why can't minoxidil be used for eyelash growth?

Pharmaceutical raw materials, Hair care materials Minoxidil can promote hair growth when used on hair, but the part we use it on is the fragile eye. Minoxidil can cause eyelid inflammation and hypertrophy, and in severe cases it can also damage the normal structure of the ocular surface. Keratin is a fibrous protein and an important component of nails, eyelashes, hair, eyebrows and other hair. Its content in the eyelash hair shaft can reach 85%-90%. Because keratin contains more cystine, it has a higher content of disulfide bonds, which play a cross-linking role in the protein peptide chain. Therefore, keratin is extremely stable in chemical properties and has high mechanical strength.

Because of the existence of keratin, the nutrition transportation and repair of hair can be maintained normally, which also ensures the unique toughness and elasticity of hair. However, with the increase of age, long-term ultraviolet radiation or improper makeup habits, the regeneration ability of hair follicles is damaged, resulting in a gradual decrease in the content of keratin, which makes eyelashes, hair and other hair become dry, yellow, easy to break, and even cannot grow normal hair. Therefore, promoting the absorption of nutrients and the growth of keratin by eyelash follicles becomes the only way to promote the growth of eyelashes.

Experimental proof

In order to confirm whether myristoyl pentapeptide-17 has the effect of promoting hair growth. The researchers applied SymPeptide 226EL (myristoyl pentapeptide-17) and SymPeptide 235EL (myristoyl pentapeptide-16) to the human epidermal model EpDermFTTM formed by culturing normal human epidermal keratinocytes, and measured the expression of keratin genes by DNA microarray after 24 hours.

The test results showed that compared with the untreated control group, SymPeptide 226EL and SymPeptide 235EL can promote the expression of keratin genes. Among them, SymPeptide 226EL increased the expression of different keratin genes by about 80%-160%. The test showed that myristoyl pentapeptide-17 can significantly stimulate the growth of keratin genes and promote hair

The subjects used SymPeptide™ 226EL containing 5% (50ppm) and 10% (100ppm) myristoyl pentapeptide-17 (once a day for 6 consecutive weeks), and measured the effects of the two concentrations on the left and right eyelashes at 2 weeks, 4 weeks, and 6 weeks using image measurement and analysis software (SigmaScan).

The test results showed that the length of the right eyelashes of the subjects in the 5% concentration group increased by 10.47%, 46.3%, and 59.14% at the 2nd, 4th, and 6th weeks, respectively; the length of the left eyelashes increased by 7.13%, 22.04%, and 26.16% at the 2nd, 4th, and 6th weeks, respectively. The left eyelash length of the subjects in the 10% concentration group increased by 46.26%, 66.39%, and 72.29% at the 2nd, 4th, and 6th week, respectively; the right eyelash length increased by 25.8%, 40.94%, and 63.19% at the 2nd, 4th, and 6th week, respectively. At the same time, the density of the left and right eyelashes of the subjects in different concentration groups increased. The experiment proved that myristoyl pentapeptide-17 can effectively promote the growth of human eyelashes.

Therefore, Beauty & Personal Care raw material myristoyl pentapeptide-17 can promote the growth of eyelashes and hair by stimulating keratin genes.